International Chemical Safety Cards

Propylene Oxide  –  Material Safety Data Sheet

 


Section 1:  Chemical Product and Company Identification


Contact Information:

FHS Supply, Inc.

244 Bethel Hill Rd

Clover,  SC 29710

PH:  1-800-742-8484

PH:  1-803-222-7488

Fax:  1-803-222-7285

E-Mail:  fhsoil@aol.com

Web:  fhsoils.com

 

Product Name:  Propylene Oxide

NA# / UN#:  1280

CAS#:    75-56-9

RTECS:  TZ2975000

TSCA:  TSCA 8(b) inventory: Propylene oxide

ICSC#:  0192

EC#:  603-055-00-4

CI#:  Not applicable

Synonym:  PO, Propene oxide,  1,2-Epoxypropane,  Methyloxirane,  Methyl ethylene oxide
Chemical Name:  Propylene oxide

Chemical Formula:  C3H6O / CH3CHCH2O

 


Section 2:  Composition and Information on Ingredients


 

Composition:

Name:                                                  CAS#                                                     % by Weight

Propylene Oxide                              75-56-9                                                 100

 

Toxicological Data on Ingredients:   Propylene oxide: ORAL (LD50): Acute: 380 mg/kg [Rat].  440 mg/kg [Mouse].  DERMAL (LD50): Acute: 1500 mg/kg [Rabbit].  VAPOR (LC50): Acute: 4000 ppm 4 hours [Rat].

 


 Section 3:   Hazards Identification


 

Potential Acute Health Effects:

Eyes:  Very Hazardous in case of eye contact, vapors and liquid may cause severe eye irritation with redness, tearing, burning, swelling of the conjunctiva and corneal burns. Damage may be permanent.

Skin:  Hazardous in case of skin contact (irritant/permeator).  Contact may cause severe irritation with redness, pain and severe burns or blisters. Propylene oxide may be absorbed through the skin in harmful amounts causing systemic effects similar to those listed under ingestion and inhalation. Propylene oxide is a skin sensitizer and may cause an allergic skin reaction. Dilute solutions may be more irritating than undiluted materials.

Ingestion:  Swallowing may cause severe burns to the mouth, throat and stomach with nausea, vomiting and diarrhea. May cause central nervous system depression with headache, dizziness, drowsiness, drunkenness and collapse.  May be fatal due to respiratory failure.  Aspiration may occur during swallowing or vomiting resulting in lung damage.

Inhalation:  Inhalation of vapors or mists may cause mucous membrane or upper respiratory tract irritation with central nervous system depression. Symptoms include headaches, dizziness, coughing, narcosis, drunkenness, incoordination, nausea, vomiting, and collapse. High vapor concentrations may cause unconsciousness, coma or death.

 

Potential Chronic Health Effects:

General Effects:  Very hazardous in case of eye contact (irritant), of ingestion, of inhalation.  Hazardous in case of skin contact (irritant permeator),  Skin: Prolonged or repeated exposure may cause delayed secondary burns, ulcers or superficial scarring. Inhalation: Studies with animals have shown chronic effects such as growth depression, lung and slight liver injury.  Ingestion:  Studies with animals have shown chronic effects such as loss of body weight, gastric irritation and slight liver injury.

CARCINOGENIC EFFECTS: Classified 2 (Reasonably anticipated.) by NTP.

MUTAGENIC EFFECTS:  Not available.

TERATOGENIC EFFECTS: Not available.

DEVELOPMENTAL TOXICITY: Not available.  The substance is toxic to lungs, mucous membranes.  Repeated or prolonged exposure to the substance can produce target organs damage.

 


 Section 4:  First Aid Measures


 

Eye Contact:

Check for and remove any contact lenses.  Immediately flush eyes with running water for at least 15 minutes, keep eyelids open.  Cold water may be used.  Do not use an eye ointment.  Get medical attention.

 

Skin Contact:

After contact with skin, wash immediately with plenty of water.  Gently an thoroughly wash the contaminated skin with running water and non-abrasive soap.  Be particularly careful to clean folds, crevices, creases and groin.  Cold water may be used.  Cover the irritated skin with an emollient.  If irritation persists, seek medical attention.  Wash contaminated clothing before reusing.

 

Serious Skin Contact:

Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream.  Seek immediate medical attention.

 

Inhalation:

Allow the victim to rest in a well ventilated area.  Seek Immediate medical attention.

 

Serious Inhalation:  Not available

 

Ingestion:

Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic material was ingested; the absence of such signs, however, is not conclusive.

 

If patient is conscious and responsive, give 4 – 8 ounces of water or milk to dilute.  Do not induce vomiting  (high risk of respiratory damage).  If vomiting occurs, Keep head lower than hips to avoid aspiration.  Loosen tight clothing such as a collar, tie, belt, or waistband.  If the victim is not breathing, perform mouth-to-mouth resuscitation.  Seek immediate medical attention.

 

Serious Ingestion:  Not available

 

MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE:  Persons with pre-existing skin, kidney, liver and respiratory disorders may be at increased risk from exposure to this substance.

 

NOTE TO PHYSICIANS:. Propylene oxide is an irritant that may cause coughing, dyspnea, noncardiogenic pulmonary edema, or chemical pneumonitis.  Cyanosis has occurred.  Lung injury has been observed in experimental animals.  Respiratory effects may be delayed.  Evaluate for respiratory distress.  Consider oxygen administration.  If a chemical burn is present, decontaminate skin and treat as any thermal burn.  No specific antidote is known, however, consider gastric lavage and administration of a charcoal slurry.

 


Section 5:  Fire and Explosion Data


 

Flammability of the Product:  Flammable

Auto-Ignition Temperature:  449°C  (840.2°F)

 Flash Points:  CLOSED CUP:  -37°C  (-34.6°F).   OPEN CUP  <-37°C  (<-34.6°F)

 Flammable Limits:  Lower: 2.3%  Upper 36%

 Products of Combustion:  These products are carbon oxides (CO, CO2)

 

Fire Hazards in Presence of Various Substances:

Highly flammable in presence of open flames and sparks, of heat.  Flammable in presence of heat.

 

Explosion Hazards in Presence of Various Substances:

Risks of explosion of the product in presence of mechanical impact:  Not available.  Risks of explosion of the product in presence of static discharge: Not available

 

Fire Fighting Media and Instructions:

Flammable liquid, soluble or dispersed in water.

SMALL FIRE:  Use DRY chemical powder.

LARGE FIRE:  Use alcohol foam, water spray or fog.  Cool containing vessels with water jet in order to prevent pressure build-up, autoignition or explosion.  Wear NIOSH-approved self-contained breathing apparatus (SCBA) operated in the pressure-demand mode and full chemical-resistant protective clothing. Evacuate all personnel from spill area and keep upwind.

 

Special Remarks on Fire Hazards:

Propylene oxide vapors are heavier than air and may travel long distances to sources of ignition and flashback.  Liquid propylene oxide is lighter than water and will float on water surfaces.  Vapors are extremely flammable and are readily ignited by static charge, sparks and flames.

 

Special Remarks on Explosion Hazards:

Propylene oxide vapors are heavier than air and may travel long distances to sources of ignition and flashback.  Vapor-air mixtures are explosive above the flashpoint.  May polymerize violently if involved in a fire.

 


 Section 6:  Accidental Release Measures


 

Small Spill:

Dilute with water an mop up, or absorb with an inert dry material and place in an appropriate waste disposal container.  Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements

 

Large Spill:

Flammable liquid.  Keep away from heat.  Keep away from sources of ignition.  Stop leak if without risk.  Blanket spill area with water fog or alcohol foam to reduce vapors. Contain and recover liquid if possible.  Use non-sparking tools and

equipment.  Absorb with DRY earth, sand or other non-combustible material.  Do not touch spilled material.  Prevent entry into sewers, basements or confined areas;  dike if needed.  Eliminate all ignition sources.  Call for assistance on disposal.  Be careful that the product is not present at a concentration level above TLV.  Check TLV on the MSDS and with local authorities.  It is mandatory to call the National Response Center (800-424-8802) if 100 pounds (45.4 kg) or more are spilled or released to the environment.

 


Section 7:  Handling and Storage


 

Precautions:

Keep locked up.  Keep away from heat.  Keep away from sparks.  Keep away from sources of ignition. Take precautionary measures against electrostatic discharges.  Ground the container while dispensing. Ground all equipment containing material.  Ground and bond containers, when transferring material.  Use spark proof tools.  Practice safe work place hygiene. Do not eat or drink near hazardous chemicals.  Do not ingest.  Do not breathe gas/fumes/vapor/spray.  Avoid contact with skin and eyes.  Wear suitable protective clothing.  In case of insufficient ventilation, wear suitable respiratory equipment.  Wash hands with soap and water after working with material.  If ingested, seek medical advice immediately and show the container or the label.    Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.

 

Storage:

Store in a segregated and approved area.  Keep container in a cool, well-ventilated area.  Keep container tightly closed and sealed until ready for use.  Avoid all possible sources of ignition ( spark or flame ).  Take precautionary measures against electrostatic discharges.  Ground all equipment containing material.  Use explosion proof equipment.  Use non-sparking tools. A refrigerated room would be preferable for materials with a flash point lower than 37.8°C (100°F)

 


 Section 8:  Exposure Controls / Personal Protection


 

Engineering Controls:

Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective threshold limit value.  Use explosion-proof ventilation equipment.  Take precautionary measures against electrostatic discharges. Ground all equipment and containers containing material.  Ensure the eyewash stations and safety showers are proximal to the work-station location.

 

Personal Protection:

Splash goggles.  Lab Coat.  Vapor respirator.  Be sure to use an approved/certified respirator or equivalent.  Boots.  Gloves.

 

Personal Protection in Case of a Large Spill:

Splash goggles.  Full suit.  Vapor respirator.  Boots.  Gloves.  A self contained breathing apparatus should be used to avoid inhalation of the product.  Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product.

 

Exposure Limits:

TWA: 20 (ppm) from ACGIH (TLV) TWA: 48 (mg/m3) from ACGIH Consult local authorities for acceptable exposure limits.

 


 Section 9:  Physical and Chemical Properties


 

Physical state and appearance:  Liquid

 Odor:  very strong.

 Taste:  Not Available.

 Molecular Weight:  58.08 g/mole

 Color:  Clear, Colorless

 pH:  (1% soln/water):  Not available

 Boiling Point:  34.23°C  (93.6°F)

 Melting / Freezing Point:  -112°C  (-169.6°F)

 Critical Temperature:  Not available.

 Specific Gravity:  0.83  (Water=1)

 Vapor Pressure:  442 mm of Hg (@ 20°C)

 Vapor Density:  2 (Air=1)

 Volatility:  Not available

 Odor Threshold:  35 ppm

 Water/Oil Dist. Coeff:  The product is more soluble in oil; Log(oil/water)=-0.9

 Ionicity (in water):  Not available

 Dispersion Properties:  See solubility in water.

 Solubility:  Soluble in cold water.

 


Section 10:  Stability and Reactivity Data


 

Stability:  The product is stable under ordinary storage and use conditions.

 

Instability Temperature:  Not available

 

Conditions of Instability:  Not available

 

Incompatibility with various substances:

Avoid acids, bases, peroxides, oxidizing agents, clay-based absorbents, polymerization catalysts, epoxy resins, anhydrous metal chlorides, copper and copper alloys, brass, bronze, and other acetylide forming metals.

 

Corrosivity:  Non-corrosive in presence of glass.

 

Special Remarks on Reactivity:

HAZARDOUS POLYMERIZATION: Polymerization may occur due to high temperatures or contamination with alkalis, aqueous acids, amines & acidic alcohols or contact with highly active catalytic surfaces.

 

Special Remarks on Corrosivity:  Not available.

May disolve some plastics, rubber, Styrofoam, and coatings.

 

Polymerization:  will not occur.

 


 Section 11:  Toxicological Information


 

Routes of Entry:  Absorbed through skin.  Eye contact.  Inhalation.  Ingestion.

                                             

Toxicity to Animals:

WARNING:  THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE.  Acute oral toxicity (LD50): 380 mg/kg [Rat].  Acute dermal toxicity (LD50): 1500 mg/kg [Rabbit].  Acute toxicity of the vapor (LC50): 4000 ppm 4 hours [Rat].

 

Chronic Effects on Humans:

GENERAL EFFECTS:  Overexposure to this product may effect the skin, eyes, respiratory system, reproductive system and central nervous system.  The substance is toxic to lungs, mucous membranes.

CARCINOGENIC EFFECTS:  Classified 2 (Reasonably anticipated.) by NTP.

 

Other Effects on Humans:

Very hazardous in case of ingestion, of inhalation.  Hazardous in case of skin contact (irritant, permeator).

 

Special Remarks on Toxicity to Animals:

CARCINOGENICITY:  Propylene oxide appears to induce cancers at the site of exposure in experimental animals.  Sarcomas occurred at injection sites, and nasal and GI cancers occurred with chronic exposure.

MUTAGENICITY:  Propylene oxide has been found to be mutagenic in experimental animals including salmonella typhimurium, escherichia coli, drosophila spermatozoa and spermatids, and neurospora crassa assays.

NEUROTOXICITY: In high concentrations propylene oxide has caused CNS effects, including CNS depression, headache, motor weakness, incoordination, ataxia, coma, and neuropathy in experimental animal studies.  Peripheral neuropathy has been reported in chronic studies with experimental animals.

TERATOLOGY:  Inhalation development toxicity studies with rats exposed to propylene oxide vapor at concentrations of 500 ppm showed fetotoxicity and developmental abnormalities.

 

Special Remarks on Chronic Effects on Humans:  Not available

 

Special Remarks on Toxicity to Humans:

MUTAGENICITY:  Human data on mutagenicity is inconclusive although propylene oxide causes DNA strand breaks in human diploid fibroblasts in vitro.  The mean chromosome aberration rate in workers with more than 20 years exposure to propylene oxides was significantly increased compared to controls.

 


Section 12:  Ecological Information 


 

Ecotoxicity:  Not available

 

BOD5 and COD:  Not available

 

Products of Biodegradation:

Possibly hazardous short term degradation products are not likely.  However, long term degradation products may arise.

 

Toxicity of the Products of Biodegradation:  The products of degradation are as toxic as the products itself.

 

Special Remarks on the Products of Biodegradation:  Not available

 


 Section 13:  Disposal Considerations 


 

Waste Disposal:

Waste must be disposed of in accordance with federal, state, and local environmental control regulations.  Contaminated solids should be landfilled only at properly permitted disposal sites using registered contractors.

Concentrated liquid waste may be incinerated (if safety precautions are taken because of very low flash point) in compliance with applicable air pollution control regulations.  It is recommended that contaminated product, soil or water intended for disposal be handled as hazardous waste due to potentially low flashpoint.

 


 Section 14:  Transport Information


 

Domestic:

Proper Shipping Name:  Propylene Oxide

US DOT Classification:  CLASS 3:  Flammable Liquid.

Packing Group:  I

NA# / UN#:  1280

 

International:

Proper Shipping Name:  Propylene Oxide

IMO Classification:  CLASS 3:  Flammable Liquid.

Packing Group:  I

NA# / UN#:  1280

 

Reportable Quantity:  100 lbs  (45.4kg)

 

North American Emergency Response Guide (EMR) Number:   127P

 

Transport Emergency Card:  TEC (R)-30S1280 or 30GF1-I+II

 

Special Provisions for Transport:  Not available.

 


Section 15:  Other Regulatory Information


 

Federal and State Regulations:

California prop. 65: This product contains the following ingredients for which the state of California has found to cause cancer, birth defects or other reproductive harm, which would require a warning under the statute.  Propylene oxide Pennsylvania RTK:  Propylene oxide Massachusetts RTK:  Propylene oxide TSCA chemical notification and release reporting: Propylene oxide

 

Other Regulations:

OSHA:  Hazardous by definition of Hazardous Communication Standards (29 CFR 1910.1200)

 

Other Classifications:

 

WHMIS (Canada):

CLASS B-2:  Flammable liquid with a flash point lower than 37.8°C (100°F).  CLASS D-1B:  Material causing immediate and serious toxic effects (TOXIC).  CLASS D-2A: Material causing other toxic effects (VERY TOXIC).

 

DSCL (EEC):

R12- Extremely flammable.  R20- Harmful by inhalation.  R38- Irritating to skin.  R41- Risk of serious damage to eyes.  R45- May cause cancer.

 

HMIS (U.S.A.)

                Health Hazard:  3

                Fire Hazard:  4

                Reactivity:  0

                Personal Protection:  h

 

National Fire Protection Association (U.S.A.)

                Health:  3

                Flammability:  4

                Reactivity:  2

                Specific Hazard:

 

Protective Equipment:

Gloves.  Lab coat.  Vapor respirator.  Be sure to use an approved/certified respirator or equivalent.  Wear appropriate respirator when ventilation is inadequate.  Splash goggles.

 


Section 16:  Other Information


 

References:  Not available

 

Other Special Considerations:  Not available

 

ERG:  127P

 

Created:  11/08/2015  12:00 PM

 

Last Updated:  11/08/2015  12:00 PM

 

The information above is believed to be accurate and represents the best information currently available to us.  However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use.  Users should make their own investigations to determine the suitability of the information for their particular purposes.  In no event shall FHS Supply, Inc. be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if FHS Supply, Inc. has been advised of the possibility of such damages.

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